Detalls de la publicació.

Article

Any:2020
Autor(s):J. Cartwright, O. Piro, I. Tuval
Títol:Chemosensing versus mechanosensing in nodal and Kupffer’s vesicle cilia
Revista:PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
ISSN:0962-8436
JCR Impact Factor:6.237
Volum:375
Número:1792
Pàgines:20190566
D.O.I.:https://doi.org/10.1098/rstb.2019.0566
Web:https://royalsocietypublishing.org/doi/10.1098/rstb.2019.0566
Resum:How is sensing carried out by cilia in the mouse node, zebrafish Kupffer’s vesicle, and similar organizer organs in other species? Two possibilities have been put forward. In the former, cilia would detect the presence of some chemical species in the fluid; in the latter, they would detect fluid flow. In either case, the hypothesis is that an imbalance would be detected between this signalling coming from cilia on the left and right sides of the organizer, which would initiate a cascade of signals leading ultimately to the breaking of left-right symmetry in the body plan of the organism. We review the evidence for both hypotheses.

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